血必净对COPD急性加重期的疗效及凝血功能的影响

Effect of Xuebijing injection on chronic obstructive pulmonary disease and blood coagulation function

目的观察血必净注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)疗效及和凝血功能的影响。方法将60例患者随机分为2组,对照组30例予以常规治疗,治疗组30例在常规治疗基础上加用血必净注射液50mL静滴,每d2次。观察2组1周后治疗效果,分别检测两组患者治疗前后凝血功能的变化。结果治疗组总有效率为90.00%,对照组为66.67%,两组相比有显著差异(P<0.01);治疗组治疗后各项检测指标与治疗前比较有显著差异(P<0.01),对照组治疗后各项检测指标与治疗前比较有显著差异(P<0.05),但治疗后治疗组各项检测指标与对照组相比有显著差异(P<0.05)。结论血必净注射液能明显改善AECOPD临床总有效率及对患者的凝血功能有保护作用,在慢性阻塞性肺疾病急性加重期的治疗过程中起重要辅助治疗作用。

Objective To observe the efficacy Xuebijing injection on patients with chronic obstructive pulmonary disease at acute exacerbation stage （AECOPD） and the impact of the drug on blood coagulation. Methods There 60 patients were randomly divided into control group consisted of 30 cases treated with conventional therapy and treatment group also conssited of 30 cases and with conventional therapy plus Xuebijing 50ml.by intravenous injection 2 times daily. The prothrombin time （PT）, thrembin time （TT）,activated partial thromboplastin time （APTT）,fibrinogen （Fbg） and platelet count （PLT） in the two groups were observed before treatment and a week after treatment. Results The results were significantly different in treatment group after treatment compared to that before treatment （P〈0.01）. The conditions of patients in treatment group were much improved after treatment compared with those of control group（P〈0.05）. Conclusion Xuebijing injection can improve the conditions of patients with chronic obstructive pulmonary disease at acute exacerbation stage and protect coagulation function of patients.