莫西沙星与左氧氟沙星治疗细菌性感染的细菌学疗效比较的Meta分析

Meta-Analysis on Microbiological Outcomes of Bacterial Infections Treated with Moxifloxacin Versus Levofloxacin

目的分析比较莫西沙星与左氧氟沙星治疗细菌性感染的细菌学疗效。方法应用RevMan4.2软件对国内2000年至2007年13项莫西沙星和左氧氟沙星治疗细菌性感染的研究进行同质性检验和合并效应量的估计。结果同质性检验χ2=11.05,自由度为10,P=0.35;合并效应量的估计OR合并=2.08,OR合并95%可信限为1.26～3.45;OR合并的检验Z=2.87,P<0.01。结论莫西沙星治疗细菌性感染的细菌学疗效优于左氧氟沙星。

Objective To compare the microbiological outcomes of bacterial infections treated with moxifloxacin versus levofloxacin. MethodsThe microbiological outcomes of 13 studies on bacterial infections treated with moxifloxacin versus levofloxacin were performed the meta- analysis using homogeneity test and combined effect test. Results Homogeneity test showed that the cited studies were homogeneous with： X^2 = 11.05, df= 10 and P =0.35; and by combined effect test, the combined OR was 2. 08 （95% confidence interval = 1.26-3.45, Z = 2.87, P 〈 0. 01）. Conclusion The efficacy of moxifloxacin injection on the microbiological outcomes of bacterial infections is better than that of levofloxacin.