气相色谱法测定布洛芬片的含量

Gas Chromatographic Determination of Ibuprofen Tablets

目的建立毛细管气相色谱法测定布洛芬片含量。方法将样品用甲醇溶解后滤过,取续滤液直接进样,用SE-30大口径石英毛细管色谱柱(30m×0.53mm,1.0μm)和FID检测器,以咖啡因为内标进行测定。结果布洛芬质量浓度的线性范围为0.1015～1.015mg/mL(r=0.9998),平均回收率为99.58%,RSD为0.56%(n=9),样品含量在97.35%～101.20%范围内。结论所用方法操作简便、快速、准确,可用于布洛芬片的含量测定。

Objective To establish a GC method for the analysis of Ibuprofen Tablets. Methods After the sample was dissolved in methyl alcohol and got filtered. The filtrate was analysed directly. The GC system included SE-30 wide bore capillary column（30 m ×0. 53 mm, 1.0μm） with flame ionization detector （F/D）, caffeine was used as internal standard. Results The linear range of ibuprofen was O. 101 5 - 1. 015 mg/mL（ r = 0. 999 8）. The average recovery rate was 99. 58%, RSD = 0. 56% （ n = 9）. The content of Ibuprofen Tablets was between 97.35% and 101.20%. Conclusion This method is simple, quick, accurate and suitable for the assay of Ibuprofen Tablets.