急性感染性腹泻患儿血清CRP值变化的临床意义

Change of Serum CRP in Acute Infectious Diarrhea in Children

【目的】探讨急性感染性腹泻患儿血清C反应蛋白（CRP）的变化及临床意义。【方法】对132例急性感染性腹泻患儿按病原体不同分为病毒性肠炎组82例和细菌性肠炎组50例；按病情程度不同分为重型腹泻组73例和轻型腹泻组59例。应用免疫比浊法测定血清CRP及血生化，同时测定53例健康对照组CRP。【结果】82例病毒性肠炎组及50例细菌性肠炎组CRP均明显高于对照组（P〈0．01），病毒性肠炎组与细菌性肠炎组比较CRP．差异无显著性（P〉0．05），73例重型腹泻组与59例轻型腹泻组比较CRP差异有显著性（P〈0．01）。【结论】急性感染性腹泻患儿CRP不能作为鉴别病毒或细菌感染的指标，但可作为评价病情严重与否的有用指标。

[Objective] To explore the change of serum C-reaction protein （CRP） level in the acute infectious diarrhea and evaluation its clinical significance. [Methods]A total of 132 cases of acute infectious diarrhea in children were divided into viral enteritis group（ n =82） and bacterial enteritis group （ n= 50） by different pathogens. According to the degree of the disease state, all patients were divided into severe diarrhea group （ n = 73） and light diarrhea group （ n = 59）. The serum CRP and blood biochemistry were measured by immunoturbidimetry method. Fifty three healthy children were selected as controls. [Results]The serum CRP level in the viral enteritis group and bacterial enteritis group was obviously higher than that in the control group（ P 〈0. 01）. There was no significant difference between viral enteritis group and bacterial enteritis group （ P 〉0.05）. There was significant difference between severe diarrhea group and light diarrhea group （ P 〈0.01）. [Conclusion] The serum CRP level in the acute infectious diarrhea can not be the indicator for distinguishing viral and bacterial infections, but it can evaluate the disease severity.