摘要
【目的】观察文拉法辛治疗脑卒中后抑郁(PSD)患者的疗效和不良反应。【方法】72例PSD患者分为文拉法辛组和阿米替林组各36例,于治疗前及治疗后第2周,第4周,第6周对两组患者进行hamilion抑郁量表(HAMD)和副反应量表(TESS)评定。【结果】治疗后,两组患者的HAMD评分均较治疗前明显降低(P〈0.01),但两组间无显著差异(P〉0.05),文拉法辛组的不良反应明显较阿米替林组少且轻(P〈0.01)。【结论】文拉法辛治疗PSD安全,有效。
[Objective] To observe the efficacy and side effects of venlafaxine in the treatment of post- stroke depression (PSD). [Methods] Seventy two patients with PSD were randomly divided into venlafaxine group( n =36) and amitriptyline group( n = 36). Before the treatment and at the end of 2nd, 4th and 6th week after the treatment, all patients in two groups were assessed with Hamilton Depression Scale (HAMD) and TESS. [Results] After treatment, HAMD scores of patients of two groups were decreased significantly ( P 〈0.01), but no difference was found between two groups ( P 〉0.05). The side effects of the venlafaxine group were obviously fewer and milder than those of amitriptyline group ( P 〈0.01). [Conclusion] Venlafaxine is an effective and safe drug in the treatment of PSD.
出处
《医学临床研究》
CAS
2009年第7期1234-1235,共2页
Journal of Clinical Research