帕罗西汀联合逍遥丸治疗慢性疲劳综合症对照研究

A contrast study of paroxetine combined with xiaoyao pill in the treatment of chronic fatigue syndrome

目的探讨帕罗西汀联合逍遥丸治疗慢性疲劳综合症的临床疗效及安全性。方法将70例慢性疲劳综合症患者随机分为两组各35例，两组均口服帕罗西汀治疗，研究组联合逍遥丸治疗，观察8w。于治疗前后采用疲劳量表-14、抑郁自评量表、焦虑自评量表评定临床疗效，副反应量表评定不良反应。结果研究组显效率85．71％、有效率91．43％；对照组分别为65．71％、88．57％。研究组显效率、总有效率显著高于对照组（P〈0．05）。两组治疗前抑郁自评量表、焦虑自评量表总分，疲劳量表-14总分及躯体疲劳、脑力疲劳因子分均无显著性差异，治疗8w末两组均较治疗前有显著下降（P均〈0．01），但研究组较对照下降显著（P〈0．05）。研究组口干、恶心发生率及副反应量表总分均显著低于对照组（P〈0．05）。结论帕罗西汀联合逍遥丸治疗慢性疲劳综合症疗效显著，不良反应发生率低、且程度较轻微。

Objective To explore the efficacy and satety of paroxetine plus xlaoyao pill in the rreatinent of chronic fatigue syndrome. Methods 70 patients were randomly divided into two groups of 35 ones each, both groups took orally paroxetine and research group was added xiaoyao pill to for 8 weeks. Before and after treatment,curative effects were assessed with the Fatigue Scale-14 （FS-14）, Self-rating Depression Scale（SDS） and Self-rating Anxiety Scale（SAS） and adverse raections with the Treatment Emergent Symtom Scale （TESS）. Results Obviously effective and effective rate were 85. 71% and 91. 43% in the research and 65.71% and 88.57 % in the control group,repectively. Obviously and total effective rate were significantly higher in the research than in the control group（P〈0.05）. Before treatment, there were no significant differences in total scores of the SDS, SAS and FS-14 as well as scores of physical fatgue and mental fatigue,those of both groups lowered more significantly at the end of the 8th week compared with pretreatment（all P〈0.01）, so did in the research than in the control group（P〈0.05）. Incidences of dry mouth and nausea and TESS total score were obviously lower in the research than in the control group（P〈 0.05）. Conclusion Paroxetine combined with xiaoyao pill has an evident effect, lower incidence of adverse reactions which are mild.