急性冠脉综合征合并糖尿病患者血清同型半胱氨酸与高敏C反应蛋白的相关性

The correlation between serum homocysteine and hs-CRP level in acute coronary syndrome patients with type 2 diabetes

目的观察急性冠脉综合征(ACS)及ACS合并有2型糖尿病患者血清中同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)及C-肽、胰岛素敏感指数(ISI)水平,探讨Hcy与hs-CRP及C-肽、ISI的相关性。方法对ACS患者60例,其中合并有2型糖尿病12例,对照组25例,测定血清中hs-CRP、Hcy、血清C肽、胰岛素水平并计算出胰岛素敏感指数。结果(1)ACS组中Hcy及hsCRP与对照组比均有明显差异(P<0.05),而且Hcy与hsCRP两者之间正相关(r=0.427,P<0.01);在ACS合并有2型糖尿病组Hcy与对照组无明显差异。(2)ACS组及合并有2型糖尿病的ACS组中血清C肽、ISI与对照组比较无明显差异(P>0.05);hsCRP在ACS及ACS合并有2型糖尿病组与对照组比较均有明显差异(P<0.01),但在ACS与ACS合并有2型糖尿病组之间无明显差异(P>0.05)。(3)Hcy与C肽、ISI无相关性;ISI与C肽呈负相关,Hcy与hsCRP相关。结论ACS患者血清Hcy与hsCRP呈正相关,与ISI及C肽无相关性。

Objective To observe the levels of serum homocysteine and hs-CRP and evaluate the correlation between homocysteine and hs-CRP in acute coronary syndrome （ACS） with type 2 diabetes. Methods 60 patients with acute coronary syndrome were divided into two groups,including 12 patinets with diabetes and 25 normal controls based on their clinical situations, electrocardiogram, coronary arteriongraphy, serum Hcy, hs-CRP and C-peptide were measured. Results The levels of serum Hcy and hs-CRP were significantly increased in patients with acute coronary syndrome compared to those of control group. The serum hs-CRP levels were higher in ACS and ACS with type 2 diabetes group than control group （P 〈 0.01 ） ; Hcy was significantly higher in ACS group than control group （ P 〈 0. 05 ）. But there was no difference between ACS with type 2 diabetes group and control group （ P 〉 0.05 ）. The correlation between homocysteine and hs-CRP level was positive in ACS ,while there was no correlation between hs-CRP and Hcy level in ACS and ACS with type 2diabetes group（ P 〉 0.05） ; No correlation was found between Hcy and C-peptide and insulin sensitivity index among ACS,ACS with type 2 diabetes mellitus and control group respectively. Conclusion There is a positive correlation between serum Hcy and hs-CRP, but no correlation between homocysteine,insulin sensitivity index and C-peptide was observed.