匹维溴胺联合氟哌噻吨美利曲辛治疗肠易激综合征伴抑郁状态疗效观察

Pinaverium bromide combined with Flupentixol and Melitracen tablets in treatment of irritable bowel syndrome with despondent

目的观察匹维溴胺联合氟哌噻吨美利曲辛对伴有抑郁状态的肠易激综合征患者的治疗效果。方法选择伴抑郁状态的肠易激综合征患者120例，完全随机分为2组，单用匹维溴胺治疗者62例为对照组，联合应用匹维溴胺及氟哌噻吨美利曲辛者58例为治疗组。对照组口服匹维溴胺50mg，3次／d；治疗组在匹维溴胺基础上加用氟哌噻吨美利曲辛片（黛力新），25mg／次，2次／d，早晨及中午服用。对患者腹痛、腹胀、腹泻、便秘、黏液便、里急后重、排便不尽感及抑郁状态进行评分，比较治疗前后评分结果。结果治疗2周及4周后，治疗组和对照组的症状学评分及抑郁自评量表（SDS）评分均有所降低，治疗组各症状评分及SDS评分较对照组差异有统计学意义（P〈0．05）。结论匹维溴胺联合氟哌噻吨美利曲辛能有效治疗肠易激综合征伴抑郁状态。

Objective To study the therapeutic effects of pinaverium bromide combined with deanxit in treatmentment of irritable bowel syndrome （IBS） with depression. Methods One hundred and twenty patients of IBS with depression were randomized into two groups. The control group were treated with pinaverium bromide 50 mg, three times per day. The treatment group were treated with pinaverium bromide 50 mg, three times per day, combined with deanxit 25 mg, twice per day. Results Two and four weeks after treatment, the semiology scores decreased in both groups. But in treatment group, the therapeutic effects of symptoms and SDS grading were significantly better than the control group （ P 〈 0.05 ）. Conclusion Pinaverium bromide combined with deanxit can effectively alleviate symptoms of IBS with depression.