喉咽癌组织中胰岛素生长因子1受体与尿激酶型纤溶酶原激活剂的表达及意义

Expression of IGF-1R and u-PALI in the laryngopharynx carcinoma

目的探讨胰岛素生长因子1受体（IGF-1R）与尿激酶型纤溶酶原激活剂（u—PA）在喉咽癌中的表达及其相互关系。方法采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶连结法（SP法），分别检测55例喉咽癌（咽喉癌组）、42例癌旁喉咽黏膜（癌旁组）及40例会厌囊肿（对照组）中IGF-1R蛋白和u-PA蛋白的表达情况。结果①IGF-1R与尿激酶型纤溶酶原激活剂u—PA在喉咽癌组、癌旁组及对照组中的阳性表达率及强阳性率依次降低（81．82％，52．38％，17．50％），3组间两两比较，差异均有统计学意义（P〈0．01）；②IGF-1R与U-PA在喉咽癌有淋巴结转移组的强阳性表达率分别为82．61％和78．26％，与无淋巴结转移组中22．22％和44．44％相比，差异有统计学意义（P〈0．01或P〈0．05）。③IGF-1R与u-PA在喉咽癌组织中的表达有明显的相关性（P〈0．01）。结论①IGF-1R和u—PA在喉咽癌组织中高表达可能与喉咽癌的发生发展有关。②检测喉咽癌组织中IGF-1R和u—PA的表达，可能有助于估计喉咽癌淋巴结转移。③IGF-1R与u—PA可能在喉咽癌发生、发展以及淋巴结转移中起了协同作用。

Objective To investigate the expressions of IGF-1R protein and u-PA protein in the tissue of laryngopharynx carcinoma and to discuss the mechanism of pathogenesis, development, invasion and metastasis of laryngopharynx carcinoma. Methods IGF-1R protein and u-PA protein were detected by immunohistichemistry SP method in 55 laryngopharynx carcinoma cases, 42 adjacent to cancer cases and 40 epiglottis cyst cases. Results ①The positive expressions of IGF-1R and u-PA protein in the tissue of laryngopharynx carcinoma, in the tissue adjacent to cancer and in the tissue of epiglottis cyst was decreased sequentially with significant differences （ P 〈 0.01 ）.②The positive expressions of IGF-1R and u-PA protein in the tissue of metastasis and non-metastasis showed statisti- cal difference（ P 〈0.01 ）. ③The IGF-1R expression was closely correlated with the u-PA expression （P 〈 0.01）. Conclusion ①IGF-1R and u-PA are related to the pathogenesis and development of laryngopharynx carcinoma.②Detection of IGF-1R and u-PA in the tissue of laryngopharynx carcinoma might help evaluate the lymphatic metastasis of laryngopharynx carcinoma.