三七总皂苷治疗强直性脊柱炎急性炎症活动期的临床研究

Clinical study on Treatment of Active ankylosing spondylitis with Total panax notoginseng sqponins

目的观察三七总皂苷治疗强直性脊柱炎急性活动期的疗效与安全性。方法62例强直性脊柱炎（AS）患者随机分为两组各31例，对照组及治疗组均常规给予非甾体消炎药（NSAIDs）、慢作用抗风湿药物（DMARDs）口服，治疗组加用含有三七总皂苷成分的血塞通注射液400mg加入200ml生理盐水中静脉滴注，1次/d。两组均治疗14d，观察治疗前后症状、体征的变化。结果两组治疗后，腰背痛改善、疼痛关节数减少、晨僵时间缩短，红细胞沉降（ESR）、C．反应蛋白（CRP）下降；两组总有效率比较，差异有统计学意义（P〈0．05）；两组不良反应发生率对比，差异无统计学意义（P〉0．05）。结论三七总皂苷和非甾体消炎药联合应用能有效控制AS的炎症活动。

Objective To evaluate the effectiveness and safety of treating active ankylosing spondylitis with total panax notogiuseng saponins（PNS）. Methods sixty-two patients were randomly recruited into a control group and a treatment group, with thirty-one patients in each group. All patients were treated with the routine therapy of NSAIDs and DMARDs. The treatment group was given PNS additionally, with 400mg PNS joined with 200ml normal saline being intravenously dripped daily. The therapeutic course was 14 days for both groups. The observation items for evaluation included symptoms, signs, and side effects. Results Compared with previous state before treatment, the lumbosacral portion pain and the count of joint pain was reduce, the time of morning stiffness was shortening, erythrocyte sedimentation rate （ESR）, and C-reaction protein （CRP） were all significantly reduced （P〈0.05） ; There were significant differences in the total effectiveness rates between the two groups （P〈0.05） ; while no notable difference was found in adverse drug reaction between the groups （P〉0.05）. Conclusion It is effective that treating active ankylosing spondylitis with PNS plus NSAIDs.