供者特异性输注诱导肾移植受者免疫耐受的研究进展

Research progress of immune tolerance induced by donor specific transfusion in renal transplantation

随着器官移植近半个世纪的发展,当前临床同种异体肾脏移植的主要热点已经转移到低毒性免疫抑制药物及其方案的应用,以及诱导移植受者产生针对供者的特异性免疫低应答或无应答技术的研究。现阶段诱导免疫耐受的有效方法,主要有供者特异性输血和供者特异性骨髓移植。文章就这两种方法的研究背景、机制以及临床应用进展进行综述。

With the development of organ transplantation for nearly half a century, currently the hot issues in clinical renal transplantation have already shifted to the application of low toxicity immunosuppressive drugs and their projects, as well as the research of technique which induces low or no immunity response to the specific donor. At present the main effective strategies of inducing immune tolerance are donor specific blood transfusion and donor specific bone marrow transplantation. This article summarizes the background, mechanism and clinical application of these two strategies.