微小RNA在肿瘤研究方面的进展

Recent progress on the research of microRNA in cance

微小RNA（miRNA）通过特异性碱基对互补调节其靶mRNA的基因表达，参与细胞的增殖、分化与凋亡过程。肿瘤细胞中miRNA表达水平与正常细胞有显著差异。miRNA可以表现为致癌基因和抑癌基因，与肿瘤的发生发展密切相关，并有望成为新的治疗靶点。

MicroRNA （miRNA） regulate the expression of target mRNA according to the specific base pairing. They are involved in proliferation, differentiation and apoptosis of cells. The expression of miRNA has distinct differences between normal tissues and cancers, miRNA can be oncogenes but also suppressor genes, they play an important role in cancer. And miRNA are promising to be a new therapeutic target. In this review, we will discuss the advance in the research of miRNA in cancer.