肿瘤热放疗基础及临床研究进展

Progress in the basic and clinical studies of malignant tumor thermoradiatherapy

肿瘤热疗可以通过抑制细胞DNA修复、改变细胞信号传导、调节细胞周期关卡及抑制肿瘤细胞转移等机制增加放射敏感性，许多临床试验也证实热放疗联合可以提高头颈部、胸腹部及盆腔恶性肿瘤的疗效。

Thermotherapy is one of the combined therapies of malignant tumor. It can enhance the sensitivity to radiotherapy by inhibiting cell DNA repair,changing cell signaling, modulating cell cycle checkpoint and inhibiting tumor cell metastasis. Many clinical trials have also confirmed that the combination of thermotherapy and radiotherapy can enhance the curative effect of head and neck, ventrum and pelvic malignant tumor. In this article,the synergistic effects and mechanism of tumor thermoradiotherapy are reviewed.