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苯并三唑化合物Bz引发4T-1乳腺癌细胞凋亡 被引量：2

Induction of Apoptosis by Benzotriazole Compound(Bz) in Mammary Cancer Cell Line 4T-1
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摘要 观察苯并三唑化合物(Bz)诱导小鼠乳腺癌(4T-1)细胞系,考察了诱导细胞凋亡的生物学效应。结果表明,Bz显著抑制小鼠乳腺癌4T-1细胞的生长,呈浓度和时间依赖性;4T-1细胞经Bz作用后,细胞增殖周期延长,增殖速度减慢,ATPase活性降低;膜电位检测结果表明,Bz能够引起细胞线粒体膜电位显著下降。Bz具有诱导小鼠乳腺癌4T-1细胞凋亡的作用,其机制可能是通过引发细胞线粒体膜电位下降而诱导细胞凋亡。 The paper investigated the effect of Benzotriazole compounds （Bz） on induction of apoptosis in mammary cancer cell line 4T-1. Bz significantly inhibited the growth of 4T-1 cells in a time and concentration-dependent manner. It was also shown that cell proliferation increased with a time and concentration-dependent manner after treatment with Bz. The activity of ATPase decreased and the mitoehondrial membrane potential collapsed. In conclusion, Bz can induce cells growth inhibition and apoptosis of 4T-1 cells may be through modulation of mitochondrial functions.
作者 孙婕 谭珍一 瞿斌
机构地区 青岛科技大学化学与分子工程学院
出处 《青岛科技大学学报（自然科学版）》 CAS 2009年第4期321-324,共4页 Journal of Qingdao University of Science and Technology:Natural Science Edition
基金 教育部留学回国人员科研启动基金第24批次资助项目
关键词 三唑类化合物 细胞凋亡 ATPASE 线粒体膜电位 benzotriazole compounds apoptosis ATPase mitochondrial membrane potential
分类号 Q279 [生物学—细胞生物学]
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参考文献13

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共引文献43

同被引文献24

  • 1李宇,李宗石.苯并三唑类紫外线吸收剂的现状及发展趋势[J].精细与专用化学品,2007,15(5):5-7. 被引量：39
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  • 3钱伯章,朱建芳.我国塑料助剂发展现状和进展[J].塑料科技,2007,35(10):92-100. 被引量：9
  • 4冀海英.新型联芳共轭有机化合物的合成及其性能研究[D]华东师范大学,华东师范大学2010.
  • 5唐林华.含吡啶环不对称三脚架配体及其配合物的合成、结构、性质研究[D]广西师范大学,广西师范大学2008.
  • 6张慧青.苯并三唑类衍生物对肿瘤细胞的影响作用[D]青岛科技大学,青岛科技大学2007.
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引证文献2

二级引证文献19

青岛科技大学学报（自然科学版）
2009年 第4期

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