新颖杀螨剂——乙螨唑的合成

The Synthesis of the New Acaricide-etoxazole

以间叔丁基苯酚为原料,制备间叔丁基苯乙醚。以2,6-二氟苯甲酰胺,氯乙醛缩二甲醇为原料,制备酰胺缩醛。间叔丁基苯乙醚和酰胺缩醛反应合成氯代酰胺。氯代酰胺在碱的存在下环合生成乙蟎唑。三步总收率40.3%(以2,6-二氟苯甲酰胺计),或44.6%(以间叔丁基苯酚计)。乙螨唑含量为95%。

2-tert-butylphenolate were prepared by 2-tert-butylphenol.The amidacetal were prepared by 2,6- difluorobenzamide and chloroacetaldehyde dimethyl acetal.The chloroamide were prepared by 2--tert--butylphenolate and amidacetal.The chloroamide is cyclized to obtain etoxazole.The total yield is 40.3%（calculated by 2,6-difluorobenzamide）,or 44.6%（ calculated by 2-tert-butylphenol）. The content is 95%.