脱氢枞胺-取代水杨醛Schiff碱的电喷雾串联质谱研究

Study on Dehydroabietylamine-substituted Salicylidene Schiff Bases by Electrospray Ionization Tandem Mass Spectrometry

采用电喷雾电离串联质谱技术对7种最新合成的脱氢枞胺-取代水杨醛Sch iff碱(DASSSB)样品进行了研究。结果显示,这些化合物的ESI-MS/MS裂解方式与它们分子中水杨醛苯环上取代基的性质和位置有关:当水杨醛苯环上4位连接供电子取代基时,分子以C N双键断裂为主,生成[M+H-283]+碎片离子;当水杨醛苯环上5位连接吸电子取代基时,分子以C N双键β位的C-C键发生断裂为主,生成[M+H-254]+碎片离子。DASSSB二级质谱产生的特征子离子可作为对此类化合物进行定性定量分析的依据。

Positive electrospray ionization tandem mass spectrometry was used to study seven novel synthesized dehydroabietylamine-substituted salicylidene schiff bases （DASSSB）. The results showed that the MS2 fragmentation pathways of DASSSB were affected by the character and position of substitutes on salicylidene phenyl. The C = N cleaving to form fragmentation ion [ M ＋ H - 283 ]^＋ was dominant for DASSSB compounds with electron-donating group on the C4 of the salicylidene phenyl; while fragmentation ion [ M ＋ H - 254 ]^＋ forming by C-C cleavage of the β-position of C=N was dominant for DASSSB compounds with electron-withdrawing group on the C5 of the salicylidene phenyl. The characteristic MS2 fragmentation ions of DASSSB can be used for the qualitative and quantitative analyses.