正己烷接触员工相关指标研究

Study of N-hexane Exposure-related Indexes in Employees

目的正己烷接触员工相关指标研究。方法选取生产工艺和生产用油墨基本相同的3个(A、B、C)印刷车间,检测3个车间现场正己烷浓度,每个车间随机抽取40名员工,测定其神经传导速度(NCV)和红细胞膜收缩蛋白(Sp)的共价交联异常情况,并观察三者的关系。选择40名办公室员工作作对照。结果C车间部分员工正中神经传导速度减慢,当正己烷浓度>44.7 mg/m3时,吸光度扫描的共价交联Sp差异有统计学意义(分别与办公室员工、A车间员工比较,P<0.05)。结论高浓度正己烷可致神经源性损害,共价交联Sp作为正己烷神经毒性的替代生物标志物有一定研究价值。

[ Objective] To study the N-hexane exposure-related indexes in employees. [ Methods] Three different workshops （A, B, C） with similar processing technique and production ink were selected. The concentration of onsite n-hexane was measured, 40 employees from each workshop were randomly selected to detect covalent cross-linking abnormalities of nerve conduction velocity （ NCV） and Erythrocyte Spectrin, and the relationships between them were observed. 40 office workers were selected for the control. [Results]The median nerve conduction velocity of some employees in workshop C decreased, when the concentration of n-hexane was more than 44.7mg/m^3 , the difference of covalent cross-linking Sp was significant by absorbance scanning （ compared with office workers and workers in A workshop respectively, P 〈0.05 ）. [ Conclusion] Neurogenic damage can be caused by high concentrations of n-hexane. Covalent cross-linking Sp as the surrogate biomarker to n-hexane neurotoxicity has a certain research value.