大Y染色体与不良妊娠关系的探讨

To explore the relationship between large Y chromosome and adverse pregnancy

目的探讨大Y染色体与不良妊娠之间的关系以及临床意义。方法常规外周血淋巴细胞培养制备染色体标本,G显带核型分析716例检测者。结果检出异常核型124例,男性异常核型56例,大Y染色体携带者38例,占男性异常核型的67.86%,可导致其配偶发生习惯性流产、生育智力低下儿、长期不育、有死胎史、有畸形儿生育史以及新生儿死亡并流产等。结论大Y染色体与不良妊娠有关,有一定的临床意义。

Objective： To explore the relationship between large Y chromosome and adverse pregnancy as well as clinical significance. Methods： Preparation of peripheral blood lymphocyte culture of conventional chromosome specimens, G - banding karyotype analysis of 716 cases were Detected. Results： Detected 124 cases of abnormal karyotype, Male 56 cases of abnormal karyotype, Large Y chromosome carriers of 38 cases, Accounting for abnormal male karyotype of 67. 86%, Large Y chromosome carriers could lead to his spouse happened habitual abortion, low infant birth intellectual, long - term infertility, history has stillbirth, children have abnormal reproductive history and neonatal deaths and abortion and so on. Conclution： Large Y chromosome was related with adverse pregnancy, and have the clinical significance.