71例自然周期IVF-ET技术临床应用分析

The application of 71 cases natural cycle in vitro fertilization and embryo transfe

目的探讨自然周期方案体外受精-胚胎移植(IVF-ET)技术在卵巢低反应、卵巢肿瘤不孕患者中的应用。方法对珠海市妇幼保健院生殖中心2007年2月至2008年11月共71例不孕症患者采用自然周期方案进行IVF-ET的临床资料进行回顾性分析。结果71例中65例是卵巢低反应,6例卵巢肿瘤因素,前者共进行78个取卵周期,取卵周期获卵率55.1%,获卵周期受精率58.1%,取卵周期胚胎移植率21.8%,临床妊娠5例,3例已分娩,2例流产,移植周期临床妊娠率29.4%,流产率11.7%。而后者,6例共进行7个取卵周期,6个周期获得卵子,取卵周期获卵率85.7%,受精率100%,取卵周期胚胎移植率57.1%,2例妊娠已分娩,移植周期临床妊娠率50%。结论自然周期方案IVF-ET对于卵巢低反应者是一种简单有效方法。对应用促排卵药物存在高风险者,同样可取得成功妊娠。

Objective： To examine the feasibility of natural cycle in vitro fertilization and embryo transfer （IVF -ET） in poor responders and the patients infertility with ovarian tumor. Methods ： The results of in - vitro fertilization in natural cycles from the February 2007 to the November 2008 in 71 infertility patients at the reproductive medicine center in Zhu Hal were analyzed. Results： 65 poor responders underwent 78 unstimulated cycles. The percentage of successful oocyte retrievals, fecundation and embryo transfers per attempted oocyte retrieval was 55.1%, 58. 1% and 21.8% respectively. A total of 5 clinical pregnancies were obtained （29. 4% per transfer） , of which 3 had delivered and 2 aborted （11. 7% per transfer）. A total of 7 unstimulated cycles were undergone in 6 infertility patients with ovarian tumors. In 7 natural cycles, 6 of the cycles retrieved the oocytes successfully. The percentage of successful oocyte retrievals, fecundation and embryo transfers per attempted oocyte retrieval was 85. 6%, 100% and 57. 1% respectively. Two of clinical pregnancies had delivered. The percentage of clinical pregnancies was 50% . Conclusion ： Natural - cycle IVF treatment is an easy and effective method for poor responder patients. And the patients can still get pregnancies by this way who might have high dangerous in using ovulation -inducing drugs.