摘要
目的应用功能连接MR成像技术观察帕金森病(PD)患者静息态脑默认状态网络的改变。方法选择14例PD患者和14名健康志愿者,以双侧后扣带回作为种子点,分别进行静息态脑功能磁共振扫描,分析PD患者与健康志愿者的脑功能连接情况和差异。结果与健康志愿组相比,PD患者的一些脑区存在异常功能连接,具体表现为:左顶下小叶、右侧楔前叶、前额叶中内侧、左侧颞上回等脑区与后扣带回功能连接减低;左侧小脑半球、左侧中央后回、左侧顶上小叶、左侧楔前叶、右侧颞下回、右侧楔叶、右侧舌回、左侧颞中回等脑区与后扣带回功能连接增强。结论静息态下帕金森病患者默认状态网络内脑区间的连接功能存在异常。
Objective To investigate the characteristics of brain default mode network of patients with Parkinson disease （PD） in resting state with functional MRI. Methods Fourteen PD patients and 14 matched controls were selected and posteriot cingulate cortex was regardes as region of interest. Results Compared with control group, brain default mode network of PD patients in resting state was abnormal, including decreased functional connectivity and increased functional connectivity. The brain areas with decreased functional connectivity included left inferior parietal lobule, right precuneus, medial prefrontal and left superior temporal gyrus. The brain area of increased functional connectivity included left cerehellar tonsil, left postcentral gurus, left superior parietal lobule, left precuneus, right inferior temporal gyrus, right cuneus, right lingual gyrus and left middle temporal gurus. Conclusion The brain default mode network of PD patients is abnormal in resting state.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第7期1156-1159,共4页
Chinese Journal of Medical Imaging Technology
基金
广东省科技计划项目(2008B080703041)
关键词
帕金森病
静息状态
磁共振成像
默认状态网络
Parkinson disease
Resting state
Magnetic resonance imaging
Default mode network
