葛根素注射液治疗椎动脉型颈椎病的临床研究

Clinical study of puerarin injection in treating cervical spondylotic vertebral arteriopathy

目的观察葛根素注射液对椎动脉型颈椎病临床疗效及对血液流变学的影响。方法随机对该病门诊及住院确诊患者分为治疗组、对照组,治疗组28例葛根素注射液静脉滴注;对照组28例复方丹参注射液静脉滴注,两组在治疗期间均辅助行颈椎牵引。观察并记录治疗前、后血液流变学检查及眩晕等症状改善情况。结果两组治疗后临床症状均明显改善,治疗组疗效优于对照组,两组间差异有统计学意义(P<0.05);治疗组治疗后,红血细胞压积、纤维蛋白原、血浆粘度均有改善,优于对照组(P<0.05)。结论葛根素注射液具有明显的增加椎动脉血流量、降低血液粘度,可明显提高治疗椎动脉型颈椎病疗效,故是治疗椎动脉型颈椎病理想的新型中药制剂。

Objective To study curative effect and hemorrheologic influence of puerarin injection in patients with cervical spondylotic vertebral arteriopathy. Methods Fifty-six outpatients and inpatients with cervical spondylotic vertebral arteriopathy were randomly and evenly divided into two groups. The treatment group was treated with puerarin injection and the control group received Salvia mihiorrhiza injection. Cervical tractions were performed in all the patients during the course of treatment. Hemorrheologic and symptomatic changes before and after treatment were observed and recorded. Results Clinical symptoms of two groups were significantly improved after treatment. The efficacy of the treatment group was superior to that of the control group and the difference between the two groups had statistical significance （ P 〈 0.05 ）. After the treatment, hematocrit, fibrinogen and plasma viscosity of the treatment group were significantly ameliorated compared with those of the control group （P 〈 O. 05）. Conclusion Puerarin injection significantly increased vertebral artery blood flow, reduced blood viscosity, and improved the therapeutic effect of cervical spondylotic vertebral arteriopathy. It was a new ideal chinese materia medica preparation for cervical spondylotic vertebral arteriopathy.