丹参对内毒素性肺损伤的保护性作用及其机理研究

PROTECTIVE EFFECT AND ITS MECHANISM OF RADIX SALIVAE MILTIORRHIZAE ON ENDOTOXIN-INDUCED LUNG INJURY

目的：研究丹参对内毒素性肺损伤的保护性作用，并探讨其作用机理。方法：采用大肠杆菌内毒素E．coliO111B4静脉注射造成内毒素性肺损伤动物模型，以丹参静脉注射进行预防研究。结果：内毒素性肺损伤组的肺系数、支气管肺泡灌洗液（BALF）中蛋白和丙二醛（MDA）及肺组织中中性粒细胞（PMN）计数均有明显增加，预先静脉注射丹参的丹参防治组上述指标均有明显下降，肺损伤程度减轻。结论：丹参对于内毒素性肺损伤有一定的防治作用，其机理可能与抑制中性粒细胞肺内聚集和抗氧自由基有关。

Aim: The Protective effect and its mechanism of radix talvae miltiorrhizae (RSM) on endotoxin-induced lung injury were studied. Methods: E. coli endotoxin O111 B4 were injected intravenously in rats to induce acute lung injury. RSM (10g/kg) was pretreated intravenously before the endotoxin. Results: Lung coefficient, the protein and MDA in BALF and neutrophils in lung tissue increased significantly in endotoxin group, while the lung coefficient, the protein and MDA in BALF and neutro phils in lung tissue were decreased in RSM group. Conclusion: RSM has the protective effect on endotoxin-induced lung injury through the inhibition of neutrophils and oxidative free radical.