有氧运动对慢性酒精中毒大鼠坐骨神经超微结构及电生理的影响

Effects of Aerobic Exercises on Microstructure of the Sciatic Nerve in the Rats with Chronic Alcoholism

目的探讨长期饮酒对大鼠周围神经功能、形态的影响,观察有氧运动能否对其功能恢复产生促进作用。方法将60只雄性Wistar大鼠随机分为三组:A对照组、B酒精中毒造模组、C康复组。以灌胃法B、C组以56%(v/v)食用酒精,A组予等体积的生理盐水,C组第10周开始予游泳训练,16周后,观察坐骨神经变化。结果(1)电生理检测示,造模组大鼠出现波幅降低,伴轻中度运动神经传导速度减慢。(2)造模组微观结构显示,神经纤维轴索变性伴继发性节段性脱髓鞘改变,而其他两组则不显著。结论早期运动训练对改善慢性酒精中毒大鼠周围神经的损伤有一定作用。

Objective To evaluate the effect of function and configuration of sciatic nerve and muscle in rat with chronic alcoholism. Methods Sixty rats were divided randomly and equally into three greups：group A（control group）,group B（ethanol group）and group C（exercise group）. The group B and group C were administered ethanol （56%, v/v）. The control group was administered isovolume normal saline. At the last 6 week, the rats of the exercise group was administered with swimming training. At last, the electromyography and histomorphometric analysis in sciatic nerve for peripheral neuropathy were evaluated in 60 rats which were exposed to ehtanol or control condition for 16 weeks. Results （1）Electrophysiologically group B showed low amplitude compared with group A and group C significantly. （2）In histomor- phometrical studies,HE in light microscope showed axonal degeneration with secondary segmental demyelination in group B. Conclusion The exercise training can improve the functional recovery of extremities in rats with chronic alcoholism.