动脉灌注联合手术治疗膀胱癌

Curative Effect of Combined Surgical Operation with Interventional Chemotherapy on Superficial Bladder Cancer

目的探讨动脉灌注联合手术治疗浅表性膀胱癌的临床疗效。方法42例浅表性膀胱癌患者随机分为A、B两组,每组21例,A组采用动脉灌注化疗加手术治疗、B组采用单纯手术治疗。结果42例随访16～32个月,平均29个月。A组患者经动脉灌注化疗后大部分膀胱病灶缩小,血尿缓解或消失,术后病理检查肿瘤细胞超微结构改变明显。A组术后复发3例(14.3%),死亡1例(4.8%)。B组术后复发10例(47.6%),死亡2例(9.5%)。A组术后复发率、死亡率低于B组(P<0.05)。两组比较化疗后副反应和并发症比较差异无统计学意义(P>0.05)。结论动脉灌注联合手术治疗浅表性膀胱癌疗效好,副反应少,临床应用安全可靠。

Objective To investigate the value of combined interventional chemotherapy and surgical operation on superficial bladder cancer. Methods 42 patients with superficial bladder cancer were randomized into group A and group B. The patients in group A were treated with preoperative arterial infusion chemotherapy ,while the patients in group B were treated by surgical operation alone. Results The patients have been followed up for 16 -32 months（mean 29 months）. Most patients＇in group A experienced a significant reduction in tumor volumes and a decrease of hematuria after chemotherapy. Significant ultrastrueture changes were observed in pathological study. 3 patients （ 14.3% ） had recurrent disease and 1 patients died （4.8%）. 10 relapse （47.6%） and 2 death （9.5%） were seen in group B. Recurrence rate and death rate in group A were significantly lower than that in group B （ P 〈 0.05 ）. The side-effect and complication rate showed no significant difference between 2 group （P 〉 0.05 ）. Conclusion Combined use of interventional chemotherapy and surgical operation is effective and safe in the treatment of patients with superficial bladder cancer.