摘要
目的观察氨磷汀对顺铂(DDP)致肾功能异常患者再化疗的肾脏保护作用。方法对19例因DDP化疗致肾功能异常患者,再次应用含DDP方案化疗,静脉用DDP前30min加用氨磷汀250mg/m2,治疗前及治疗后不同时间分别测定血尿素氮、血肌酐值,观察肾功能的变化情况。结果19例患者,有效4例,稳定12例,进展3例,总有效率达84.2%。结论DDP化疗后肾功能轻度异常患者,再次采用含DDP方案化疗时,加用氨磷汀可以防止肾功能的进一步损害。
Objective To observe the protective effect of amifostine on the patients using cisplatin - based chemotherapy again,whose nephrotoxicity had been induced by cisplatin. Methods 19 patients whose renal function had been damaged by cisplatin received cisplatin -based chemotherapy again. Amifostine 250 mg/m^2 was used 30 minutes before injection of cisplatin. The indicators included blood urea nitrogen and creatinine being assayed before and after the chemotherapy to observe the amelioration of renal function. Results The total effective rate was 84.2% in the 19 patients, with CR 4 cases, SD 12 cases, PD 3 cases. Conclusion Amifostine used before cisplatin - based chemotherapy can protect the renal function having been damaged by cisplatin from further being destroyed.
出处
《实用癌症杂志》
2009年第4期386-387,410,共3页
The Practical Journal of Cancer
关键词
氨磷汀
肾脏毒性
顺铂
Amifostine
Nephrotoxicity
Cisplatin
