消化道小细胞癌免疫表型及其临床病理意义

Small Cell Carcinoma of the Alimentary Tract:Clinicopathological Observation of 30 Cases

目的探讨消化道小细胞癌的临床病理和免疫表型特征,以指导其病理诊断和鉴别诊断及临床治疗、评估预后。方法对30例消化道小细胞癌行临床病理形态学观察和免疫组织化学检测。结果光镜形态:小细胞型15例;中间细胞型7例;混合型8例。免疫表型:EMA阳性21例,NSE阳性18例,Keratin16例,CgA10例,S-100蛋白阳性5例,vimentin均阴性。结论EMA、NSE、Ker为小细胞癌的较为可靠的标记物,支持此瘤来源于内胚层全能干细胞。

Objective To study clinicopathological and immunohistochemical characteristics of small cell carcinoma of alimentary tract. Methods Thirty cases of small cell carcinomas were investigated with clinicopathological observation and immunohistochemical analysis. Results Histologically,they were divided into three types：15 cases were small cell carcinoma, 7 cases were intermediat cell type,8 cases were mixed cell type. Immunohistoehemical results showed as follows ：EMA , NSE, Ker, CgA, S - 100 were positive in 21,18,16,10 and 5 cases ,respectively. All 30 cases were negatively for Vim. Conclusion EMA,NSE, Ker are useful markers of small cell carcinoma of the alimentary tract. The results support the hypothesis that small cell carcinoma of the alimentary tract may derive from the totipotent primitive cell.