sol-CXCL16在急性冠脉综合征患者中的表达规律

sol-CXCL16 and Hs-CRP in Patients with Acute Coronary Syndrome in the Expression of the Law

目的:初步探讨sol-CXCL16在急性冠脉综合征(ACS)患者中的表达规律及临床意义。方法:将50名稳定型心绞痛(SAP)患者,50名ACS患者分为常规治疗组和强化他汀治疗组。分别在治疗2周和4周后测定sol-CXCL16和hs-CRP的浓度。结果:常规治疗组sol-CXCL16水平和hs-CRP水平无明显相关关系(r=0.169,P>0.05);治疗2周后:强化他汀治疗组sol-CXCL16浓度较常规治疗组及治疗前均有明显下降(P值均<0.05);治疗4周后强化他汀治疗组sol-CXCL16及hs-CRP浓度均较常规治疗组及治疗前有明显的下降,且差异有统计学意义(P值均<0.05)。结论:研究提示sol-CXCL16浓度的升高与ACS虑者独立相关,并可能在评估ACS危险分层和治疗效果有一定的作用。

Objective：Preliminary Study on sol-CXCL16 in patients With acute coronary syndrome （ACS） patients and clinical significance of expression of the law.Methods：To 50 with stable angina pectoris （SAP） patients,50 ACS patients were divided into conventional treatment group and strengthen the statin treatment group,Respectively, in the treatment of two weeks and 4 weeks after the determination of sol-CXCL16 and the concentration of hs-CRP.Results：Conventional treatment group soI-CXCL16 levels and hs-CRP level of no significant correlation （r = 0.169,P〉 0.05）;2 weeks after treatment：enhanced statin treatment group than the concentration of sol-CXCL16 and the cenventional treatment group before treatment were significantly decreased （P value 〈0.05）;4 weeks after treatment to strengthen statin treatment group sol-CXCL16 and hs-CRP concentration than those of conventional treatment group and pre-treatment significantly decreased And thc difference was statistically significant （P Value 〈0.05）.Conclusions：Suggests that the concentration of sol-CXCL16 in patients wich clevated independently associated with ACS,Suggests that the concentration of sol-CXCL16 in patients with elevated independently associated with ACS.