胆木叶的抗炎镇痛作用研究

Study on the Anti-inflammation and Analgtic Effect of the Leaves of Nauclea Officinalis Pierre Ex Pitard

目的:研究胆木叶的抗炎、镇痛作用。方法:采用对二甲苯致小鼠鼠耳肿胀的影响、对二甲笨致小鼠毛细血管通透性的影响来观察胆木叶的抗炎作用;采用热板法和扭体法来考察胆木叶的镇痛作用。结果:胆术叶醇提物(20g/kg)具有抑制二甲苯所致小鼠鼠耳肿胀的作用(P<0.01)、具有抑制二甲苯所致小鼠毛细血管通透性的作用(P<0.01);能明显抑制热板所致的小鼠疼痛(P<0.01)、能明显抑制醋酸所致小鼠的疼痛作用(P<0.05)。结论:胆木叶醇提物(20g/kg)具有抗炎和镇痛作用。

Objective：To study the anti-inflammation and analgtic effects of the leaves of nauclea officinalis pierre ex pitard. Methods：Anti-inflammation effect was studied with the methods of observing the effect on capillary permeability of mice ear swelling induced by dimethylbenzene.Hot-plate and writhing test were adopted to study the analgesic effect of the leaves of Nauclea officinalis pierre ex pitard.Results：The alconol extract of leaves of nauelea officinalis pierre ex pitard had an inhibitory effect on ear swelling（P〈0.01）and capillary permeability induced by xylene in mice（P〈0.01）;The pain during hot plate test（P〈0.01）and induced by acetatc（P〈0.05）in mice could be significantly inhibited by it.Conclusions：The leaves of nauclea officinalis pierre ex pitard had the effect of anti-inflammation and analgesia.