婴幼儿喘息者外周血白细胞介素-4受体基因多态性表达的研究

Polymorphism of IL-4 receptor gene in patients with childhood wheezing

对128例住院的婴幼儿喘息患者和82例同期健康婴幼儿，应用PCR-限制性内切酶酶切法进行白细胞介素-4受体基因150V和Q576R检测。患儿与正常儿童150与V50、Q576与11576等位基因频率和基因型频率之间存在差异，150／150基因型与喘息的易感性相关（P=0．015，OR=0．439，95％CI=0．223～0．826），150／150和Q576／R576的组合与喘息发病的易感性有关。说明携带易感基因的儿童可能容易发生反复喘息乃至以后的哮喘。

The study consisted of 128 children with wheezing and 82 heahhy subjects. PCR-RFLP was used to detect IL-4R gene ISOV and Q576R. There were difference in I50 and V50, Q576 and R576 allele frequency and genotypic frequency between childhood wheezing patients and normal children. Genotype I50/I50 was correlated with the susceptibility for wheezing （P =0. 015, OR =0. 439, 95% CI = 0. 223 - 0. 826）. The susceptibility for wheezing was related to the combination of I50/I50 and Q576/R576. Results of this study suggest that childhood wheezing is closely related to genetic factors, and children who carry predisposing genes may suffer from frequent wheezing and subsequent asthma.