原发性胸腺癌8例临床诊治分析

Diagnosis and Surgical Treatment of 8 Cases of Primary Thymic Carcinoma

目的探讨原发性胸腺癌的诊断方法和外科治疗效果。方法对8例手术治疗并经病理证实的原发性胸腺癌患者的临床资料进行回顾性分析。结果MasaokaⅢ期7例,Ⅳ期1例,手术切除率87.5%(7/8),术后7例放疗,辅加化疗3例。随访12～78个月,1年生存率为100.0%,3年生存率为62.5%,有1例复发,4例转移。结论原发性胸腺癌是一种少见的恶性肿瘤,CT和穿刺检查是主要的诊断方法,早期诊断率很低,首选彻底切除肿瘤组织+放疗的综合治疗,预后差。

Objective To investigate the diagnosis and the surgical therapeutic efficacy of primary thymic carcinoma. Methods The clinical data of 8 cases with primary thymic carcinoma confirmed by pathology were analyzed retrospectively. Resuits According to Masaoka staging,7 cases was stage Ⅲ and 1 case stageⅣ. Rate of surgical excision is 87.5% （7/8）. 7 cases underwent postoperative radiotherapy,and 3 cases with adjuvant chemotherapy. The follow up was 12 to 78 months. Survival rate of one year was 100%, 3 years was 62.5 %, in which recurrence occurred to 1 case, and metabasis to 4 cases. Conclusion Primary Thymic Carcinoma is a kind of rare malignant tumor with unsatisfactory prognosis. The major diagnostic method is CT and preoperative pricking examination. The ratio of early diagnosis is very low. The surgical excision of tumor tissue combined with radiotherapy are first choose for primary thymie carcinoma.