联合给药治疗慢性细菌性前列腺炎临床观察

Effect of Co-administration of Medicines in Curing the Bacterial Chronic Prostatitis

目的探讨经肛门联合口服给药治疗慢性细菌性前列腺炎的临床疗效。方法将慢性细菌性前列腺炎患者508例随机分成三组,年龄(21～49)岁,平均(32±9)岁。第1组:经肛门塞入野菊花栓和氟嗪酸栓组(148例);第2组:口服阿奇霉素片、左氧氟沙星片组(161例)。第3组:经肛门塞入野菊花栓和氟嗪酸栓联合口服阿奇霉素片组(199例)。对治疗前和治疗2月后患者自觉症状评分;2次前列腺液(EPS)常规及病原学检查进行对比。结果①第1组患者痊愈率53.1%,有效率85.3%;第2组痊愈率43.9%,有效率66.9%;第3组患者痊愈率77.4%,有效率87.9%。第3组与第1,2组对比差异有统计学意义(P<0.05)。②不良反应发生率第1组11.9%,第2组14.6%,第3组14.1%,三组对比差异无统计学意义(P>0.05)。结论经肛门联合口服给药治疗慢性细菌性前列腺炎较单纯肛门给药或单纯口服给药疗效明显,值得临床推广使用。

Objective To observe the efficacy of anorectal treatment combined with taking pills in curing the bacterial chronic prostatitis. Methods 508 bacterial chronic prostatitis patients were randomly divided into three groups, the average age of the patients was 32 ±9（21-49）. 148 patients in group 1 were treated anorectaUy with wild chrysanthemum suppositories and Ofloxacin suppositories. 161 patients in group 2 were treated with Azithromycin and Levofloxacin pills. 199 patients in group 3 were treated anorectally with wild chrysanthemum suppositories and Ofloxacin suppositories combined with taking Azithromycin pills. Accord- ing to the patients, symptoms, the scores were recorded; EPS-Rt and pathogen examination were performed before and after two months of treatment. Results The curative rate in group 1,2 and 3 was 53.1% ,43.9% and 77.4% respectively. The total effective rate in group 1,2 and 3 was 85.3% ,66.9% ,and 87.9% respectively. The curative rate and total effective rate in group 1 was significantly higher than those in group 2 and 3 （ P 〈 0. 05 ）. The adverse effect rate in group 1,2 and 3 was 11.9%, 14.6% and 14.1% respectively, there was no significant difference between the three groups （P 〉 0.05 ）. Conclusion Treated anorectally combined with taking pills in curing the bacterial chronic prostatitis was more effective than simplely cured anorectally or taking pills only. It was worthy to be popularized.