盐酸多奈哌齐与尼莫地平治疗血管性痴呆的疗效观察

Comparative Effect of Donepezil and Nimodipine on Vascular Dementia

目的观察盐酸多奈哌齐与尼莫地平治疗血管性痴呆的疗效。方法将36例血管性痴呆患者随机分为盐酸多奈哌齐组20例,给予盐酸多奈哌齐5mg,每日1次口服,疗程12周;尼莫地平组16例,给予尼莫地平组30mg,每日3次口服,疗程12周。观察用药前后认知功能(MMSE)及日常生活能力(ADL)改善程度。结果盐酸多奈哌齐可明显改善认知功能和日常生活能力,尼莫地平可改善认知功能障碍,但疗效不如盐酸多奈哌齐,且不能提高日常生活能力。结论盐酸多奈哌齐与尼莫地平均可用于治疗血管性痴呆,盐酸多奈哌齐疗效优于尼莫地平。

Objective To compare the effect of donepezil and nimodipine on vascular dementia. Methods Thirty-six patients with vascular dementia were randomly divided into donepezil group （n = 20 ） and nimodipine group （n = 16 ）. Donepezil group were treated with donepezil at a dose of 5 mg daily for 12 weeks. Nimodipine group were treated with nimodipine at a dose of 30 mg three times daily for 12 weeks. Before and after the treatment, mini-mental state examination （MMSE）and activities of daily living（ADL） were appraised. Results Donepezil significantly improved cognitive function and activities of daily living in patients with vascular dementia. Compared with donepezil, nimodipine had less effect on improvement of cognitive function, and had no effect on activities of daily living in patients with vascular dementia. Conclusion Both donepezil and nimodipine have effect on vascular dementia, but donepezil are more effective than nimodipine.