摘要
目的探讨血浆脂联素(APN)和D-二聚体在急性心肌梗死(AMI)患者中的变化及其临床意义。方法选择AMI患者50例,入院后均行超声心动图检查评价室壁运动和心功能,并设对照组(30例)进行比较。采用ELISA法测定APN,免疫比浊法测定D-二聚体水平。结果AMI患者APN水平显著低于正常心功能对照组(P<0.01),D-二聚体水平显著高于正常心功能对照组(P<0.01)。AMI患者APN、D-二聚体水平与左心室射血分数(LVEF)呈负相关(r=-0.549,P<0.01)。结论血浆APN、D-二聚体水平与预后显著相关,对AMI的辅助诊断、疗效观察及预后判断具有重要价值。
Objective To explore the changes and significance of plasma adiponectin（APN） and D-Dimer in patients with acute myocardial infarction（AMl）. Methods 50 AMI patients and 30 normal individuals were observed. Plasma concentration of APN was measured by ILISA and D-Dimer was measured by turbidimetric immunoassay. Results The concentration of APN in patients with AMI was significantly lower than those in the control group（ P 〈 0.01 ）, D-Dimer was significantly higher than those in the control group（P 〈 0.01 ）. The concentration of APN and D-Dimer in AMI patients had a parallel relationship with LVEDD （ r = - 0.549,P 〈 0.01 ）. Conclusion Plasma APN and D-Dimer level were of great value to the diagnosis, treatment and prognosis of AMI.
出处
《中华全科医学》
2009年第9期949-950,共2页
Chinese Journal of General Practice
