2型糖尿病合并无症状性脑梗塞35例临床分析

Clinical Analysis of 35 Cases of Type 2 Diabetes Mellitus with Asymptomatic Cerebral Infarction

目的探讨2型糖尿病患者合并无症状性脑梗死(ACI)的临床特点及危险因素。方法67例ACI均为2000年1月～2008年12月我院门诊及住院患者,其中2型糖尿病合并ACI35例为观察组,非糖尿病并ACI32例为对照组,比较两组临床表现及影像学改变(头颅CT或MRI、颈动脉彩超),并对血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(Fbg)、体重指数(BMI)的结果进行分析。结果糖尿病组以多灶性脑梗死、颈动脉粥样硬化多见,血TC、LDL-C、Fbg、BMI与非糖尿病组之间比较差异具有显著性(P<0.05)。结论2型糖尿病合并ACI有关的危险因素较多,积极干预危险因素是防治的重要手段。

Objective To investigate the clinical character and risk factors of type 2 diabetes mellitus with asymptomatic cerebral infarction （ACI）. Methods The 67 cases of ACI out patient and in patient with were divided into two groups from January 2000 to December 2008 in our hospital, the investigation group included 35 cases of type 2 diabetes mellitus with ACI, while the control group included 32 cases of non-diabetes with ACI. The clinical manifestations and imaging changes （skull CT or MRI and color Doppler ultrasound） were compared, the indexes of TC, LDL-C, Fbg, BMI were observed and analyzed. Results Most of the type 2 diabetes mellitus with ACI were multifocal brain infarction and carotid atherosclerosis, and there were significant differences between the investigation group and the control group（P〈0.05）. Conclusion Type 2 diabetes with ACI has many risk factors, of which more active intervention is an important method for prevention and treatment of the disease.