氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效观察

Observation of effects of clopidogrel combined with aspirin on unstable angina pectoris

目的探讨氯吡格雷(波立维)与阿司匹林联合应用治疗不稳定型心绞痛的临床疗效、安全性及远期心血管事件的发生率。方法将出现症状后24h内就诊的168例不稳定型心绞痛患者随机分成2组,观察组84例在服用阿司匹林100mg,每天1次的基础上给予波立维即刻300mg,随后75mg,每天1次;对照组84例单用阿司匹林,治疗持续均9～12个月。结果观察组总有效率为80.95%高于对照组的69.05%,差异有统计学意义(P<0.05)。非致死性心肌梗死的发生率,观察组9.52%、对照组13.10%。观察组发生出血的患者占3.6%略多于对照组2.4%,但未出现危及生命的出血。结论新型抗血小板药物波立维和阿司匹林联合应用可明显地改善不稳定型心绞痛的症状及预后,优于单独应用阿司匹林的效果。

Objective To explore the therapeutic effect ,safety and the usance rate of angiocardiopathy of clopidogrel combined with aspirin in treating the unstable angina pectoris.Methods 168 patients with unstable angina pectoris who visiting within 24 hours were randomly divided into two groups.84 cases of the control group were treated by aspilin lasts 9 to 12 months,while the observation group was added clopidogrel 300mg and than 75mg per day on the bases of aspirin 100mg per day.Results The total effective rate in observation group was 80.95% that higher than the control group obviously 69.05%(P<0.05).The incidence rate of nonfatal myocardial infarction was 9.25% in observation group,and 13.10% in control group.The patients who hemorrhage in observation group was 3.6%,significantly higher than 2.4% in control group,but it wasn't threat to life.Conclusion Clopidogrel combined with aspirin can be used to improve on the symptom and prognosis in unstable angina patients and be better than used aspirin alone.