沙利度胺治疗强直性脊柱炎65例临床观察

Clinic Observation of Treatment of 65 cases of ankylosing spondylitis with Thalidomide therapy

目的观察沙利度胺治疗强直性脊柱炎(AS)的临床疗效。方法将65例AS患者随机分成2组,治疗组30例应用沙利度胺治疗,对照组35例应用柳氮磺胺嘧啶(SASP)治疗,观察2组外周关节肿胀数、关节疼痛数、扩胸度、枕壁试验、关节指数、功能指数、红细胞沉降率(ESR)、C反应蛋白(CRP),对比2组临床疗效。结果治疗组显效率+临床缓解率为80.0%明显高于对照组的57.1%(P<0.05),治疗组达显效和临床缓解的时间为(45.0±15.6)d和(90.0±19.8)d分别短于对照组的(120.0±23.6)d和(180.0±29.4)d,差异均有统计学意义(P<0.01)。结论沙利度胺是一种治疗AS的有效的药物,值得临床应用。

Objective To observe the curative effects of Thalidomide on AS. Methods 65 cases of AS sufferers divided into two groups randomy. The treatment group （30 cases ）was theated with Thalidomide . The control group （35 cases） was theated with SASP. After treatment articular pain and swelling, degree of thoracic dilation, ESR and CRP ete were examined to observe the clinical effects. Results The treatment group obviously efficienly add dinical alleviation rate is 80.0% that higher than the control group obviously 57.1% （P 〈 0.05 ）. The treatment group reaches the appearance and the clinical alleviation time is （45.0 ± 15.6） days and （90.0 ± 19.8 ） days that distinguishes short in control group＇s （ 120.0 ±23.6 ） days and （ 180.0 ±29.4）, and the difference has statistics significant. Conclusion Thalidomide is effective in treatment of AS , so its ought to spread to use.