烧冲复合伤后内皮素和一氧化氮的变化及其意义

Study of the changes and significances of endothelin and NO after combined burn-blast injury in rats

目的：探讨烧冲复合作后肺组织内皮素（ET）和一氧化氮（NO）的变化特点及其意义。方法：检测伤后不同时间肺组织ET和NO含量的变化，并对伤后大鼠给以内皮素受体（ETR）拮抗剂和一氧化氮合酶（NOS）抑制剂干预治疗，观察肺脏的大体和镜下改变，结果：伤后肺组织ET、NO含量及ET／NO比值均出现了明显变化，ET／NO比值变化与伤情呈显著正相关。ETR拮抗剂和NOS抑制剂分别可减轻和加重肺损伤。结论：伤后肺组织ET／NO比值升高，ET和NO之间平衡被破坏，这对烧冲复合伤肺损伤的发展具有重要意义。

Objective: To study the effects of endothelin (ET) and nitric oxide (NO) after combined burn-blast injury. Methods: We investigated the contents of ET and NO in pulmonary tissues after combined burn-blast injury in rats, and administered endothelin receptor (ETR ) antagonist and nitric oxide synthase (NOS) inhibitor to observe the pathological changes in pulmonary tissues. Results: The contents of ET .NO and ET/NO ratio in pulmonary tissues changed significantly after injury, ET/NO ratio was significantly positively correlated with the pulmonary pathological changes. ETR antagonist improved the pathological changes and NOS inhibitor aggravated the pathological changes after combined injury. Conclusion: ET/NO ratio increased significantly after injury, the balance between ET nad NO was broken down, which played an important role in the development of injury.