过度使用血管扩张剂治疗对急性脑梗死疗效的影响

Impact of Excess Use Vasodilator Agent on Acute Cerebral Infarction

目的:观察过度使用血管扩张剂治疗对急性脑梗死疗效的影响。方法:依据血管扩张剂的使用情况,将497例急性脑梗死患者分成两组,第一组使用血管扩张剂2种(含)以下,第二组使用血管扩张剂3种(含)以上。总结分析两组病例急性期治疗阶段的疗效,包括神经功能缺损评分、短暂病情加重病例数(发生率)、进展性脑卒中病例数(发生率)。结果:第一组患者的临床神经经功能缺损评分16.3±1.8优于第二组19.4±1.7,P<0.01;第一组患者的短暂病情加重发生率(8.42%)低于第二组(21.86%),P<0.01;第一组患者的进展性脑卒中的发生率(11.36%)低于第二组(19.2%),P<0.05。结论:过度使用血管扩张剂对急性脑梗死的疗效有负面影响。

Objective： To observe impact of excess use vasodilator agent therapy to curative effect with acute cerebral infarction. Method： 497 patients with acute cerebral infarction was fraetionated 2 groups, First group had accepted therapy with 2 kinds or 1 kind of vasodilator agent; second group had accepted therapy with 3 or overtopping 3 kinds of vasodilator agent. To compare score of neurologic impairment, incidence of the patient＇s condition transient exacerbation and stroke in progression. Result： The score of neurologic impairment in 16.3 ± 1.8 the first group patients is outweigh second group patient that is 19.4 ±1.7 ,P 〈0. 01 ; Incidence of condition transient exacerbation is 8.42% in the first group patient is lower than 21.86% in the second group patient, P 〈0.01 ;Incidence of stroke in progression is 11.36% in the first group patient is lower than 19.2% in the second group patient, P 〈0.05. Conclusion： Excess use vasodilator agent has negative influence on curative effect with acute cerebral infarction.