肟的清洁还原研究

Study on the Clean Reduction of Oximes

文章报道在超临界二氧化碳中,以锌粉和水还原肟,生成胺与二氧化碳形成胺基甲酸胺盐,经碱处理可以得到相应的胺。其产物伯胺与体系中的CO2生成氨基甲酸胺盐阻止了其与中间体亚胺的作用从而使伯胺成为主要产物。还探讨了二氧化碳压力、反应温度、反应时间对转化率的影响。结果表明,在优化条件(反应温度100℃,CO2压力8MPa,反应时间6h)下,锌和水可以顺利地把肟还原成胺。

The paper reported that oximes were reduced into amines by zinc and water in supercritical carbon dioxide, the afforded primary amines then transformed into carbamate with carbon dioxide, which prevented primary amines from reacting with the intermediate imines, and primary amine was the major product as a result. The pressure of CO2, temperature and time were examined and the research suggested that oximes could be reduced into amines by zinc and water at in scCO2 under the optimized conditions （ temperature 100 ℃, 8 MPa CO2, time 6 h）.