急慢性乙型肝病临床与肝组织中Fas抗原和Fas配体表达的原位研究

Fas Antigen and Fas Ligand Expression in Liver Tissues of Patients WITH Acute and Chronic Hepatitis B and Liver Ddiseaes

为探讨ＣＴＬ－Ｆａｓ－ＦａｓＬ系统在急慢性乙型肝病中的作用，本文采用免疫组化法对１１０例急慢性乙型肝病组织中的Ｆａｓ抗原和ＦａｓＬ的表达进行了检测。结果Ｆａｓ和ＦａｓＬ的表达率急性乙肝分别为５５．３％和６０．５％、慢性乙肝８７．０％和８４．８％、肝硬化８０．０％和７０．０％、慢重乙肝１００％和１００％（Ｐ＜０．０５）；慢性乙肝其肝组织Ｆａｓ和ＦａｓＬ的表达强度与患者的年龄、性别和血清ＡＬＴ水平无关，而与血清Ａ、Ａ／Ｇ、ＰＴＡ和ＴＢＩＬ水平有关。结果表明，由ＣＴＬ－Ｆａｓ－ＦａｓＬ系统介导的肝细胞凋亡。

Fas antigen and Fas ligand(FasL)expression were detected by immunohistochemical methodes in 100 liver samples from patients with acute and chronic HBV infection.The results indicated that the prevalance of Fas antigen and FasL expression in acute hepatilis B,chronic hapatitis B,and cirrhosis was respectively 55.3% and 60.5%,87.0% and 84.8%,80.0% and 70.0%(P<0.05).In chronic hepatitis B,serum ALT and TBIL levels were higher in Fas antigen and FasL-positive cases than in negative cases,No significant difference at age,sex,serum albumin(A),A/G,prothrombin time(PTA) between the Fas antigen and FasLpositive groups and negative groups,and there was a positive correlation between severity of inflammation and the degrees of Fas antigen and FasL expression.These findings suggest that CTL-Fas-FasL system may play an important role in inflammation in acute and chronic liver diseases.