经内镜中西药物治疗溃疡性结肠炎临床研究

Clinical Studies on Chinese and Western Drugs with Endoscope in Treatment of Ulcerative Colitis

目的:观察经内镜中西药物治疗溃疡性结肠炎(UC)的疗效。方法:采用随机对照观察,将符合入选标准的79例UC患者分为治疗组(49例)、对照组(30例)。治疗组经内镜喷洒中西药液100ml并口服柳氮磺嘧啶(SASP),对照组口服SASP和强的松。结果:治疗组和对照组的临床有效率分别为95.9%、76.7%,治疗组显著优于对照组(P<0.01);腹泻,腹痛、黏液血便总有效率治疗组分别为91.5%、93.3%、97.5%,对照组分别为80.0%、%(P<0.01)。治疗组未见明显不良反应,对照组以恶心、上腹不适为多见(33.3%),白细胞减少次之(16.7%),皮疹(3.3%)。结论:经内镜中西药物治疗溃疡性结肠炎有较好疗效,可在临床中推广使用。

Objective： To observe the therapeutic results of chinese and western drugs with endoscope in treatment of ulcerative colitis（uc）. Methods：A randomized double-blind control study was performed to observe 79 patients with UC that were matched with selected standard and included 49 cases in therapeutic group and 30 cases in control group . Therapeutic group was sprayed 100mL of chinese and western drugs with endoscope, and was given SASP;and control group was given SASP and hydroprednisone.Results：It was showed significant difference that the clinical effective rate of the therapeutic group and the control group was 95.9% and 76.7% respectively（P〈0.01）; Total effective rate on diarrhea, bellyache and mucilage bloody stools was 91.5% , 93.3%, 97.5% respectively in the therapeutic group and 80.0%, 68.2%, 66.7% in the control group. Compared with the control group , the therapeutic group had advantages in treating bellyache and mucilage bloody stools （P〈0.05） and according to the clinical effect observed by endoscope ,the effective rate was 73.5% and 46.7%respectively （P〈0.01） , there was no obvious side-effect in the therapeutic group, while the symptoms such as nausea and epigastric discomfort （33.3 %） , decrease of white blood cell （16.7%） and skin rash （3.3 %） existed in the control group. Conclusion：Chinese and western drugs with endoscop in treatment of UC may bring forth better curative effect,which should be widely used in the suffasalazine.