血清可溶性白介素-2受体测定在丙型肝炎及干扰素治疗中的意义

The Significance of Serum Soluble lnterleukin-2 Receptor in Patients with Hepatitis C and on Interferon Treatment

采用ELISA法测定了60例丙型肝炎患者血清sIL-2R水平。结果显示,丙型肝炎患者血清sIL-2R水平明显高于正常对照组(P<0.01),急性肝炎高于慢性肝炎(P<0.01)。肝功能损害程度与血清sIL-2R水平呈正相关(r=0.57,P<0.01)。29例HCV-RNA阳性患者应用α-2b干扰素治疗,治疗后血清sIL-2R较治疗前明显下降(P<0.05),其中17例HCV-RNA阴转,阴转组较未阴转组下降明显(P<0.05)。结果提示:血清sIL-2R水平与丙型肝炎患者肝细胞病变程度有关,同时对观察干扰素的疗效亦有所帮助。

To study the significance of serum soluble interleukin-2 receptor(sIL-2R)in patients with hepatitis C and on interferon treatment. The levels of serum sIL-2R were measured by ELISA in 60 patients with hepatitis C( including 21 cases of acute hepatitis and 39 of chronic hepatitis). The levels of serum sIL-2R in patients with hepatitis C were higher than those of normal controls(P<0.01),the sIL-2R levels in acute hepatitis were higher than those in chronic hepatitis(P<0.01). The degree of liver cells damage had positive correlation with the levels of serum sIl-2R(r = 0.57,P<0.01).29 patients were treated with interferon -α2b.The results showed that the sIL-2R levels were decreased after treatment(P<0.05). The levels of sIL-2R in post-treatment HCV-RNA negative group were significantly lower than those of HCV-RNA positive group(P<0.05). The results suggested that the levels of sIL-2R may be closely related to the degree of liver cells damage and can be used as a reference index of the curative effects of IFN.