北京市西城区1985～1995年百日咳发病与预防接种效果综合分析

The Synthetic Analysis on the Occurrence of Pertussis and Its Vaccine Efficacy Druing 1985-1995 in Xicheng District

北京市西城区１９８５～１９９５年百日咳疫苗的基础免疫和加强免疫接种率始终保持在９８％的高水平，百日咳报告发病率逐年下降。至１９８９年使用的是非吸附百白破混合制剂（ＤＰＴ），１９９０年换用吸附ＤＰＴ，两者的抗体阳性率相似，但抗体保护率不同，后者明显高于前者，差异有显著的统计学意义。吸附ＤＰＴ的抗体几何平均滴度（ＧＭＴ）比非吸附ＤＰＴ高６．７倍。北京市西城区１９９２～１９９５年百日咳发病为０。分析认为，在保持高接种率的基础上，提高百日咳抗体保护率和ＧＭＴ水平，是控制和消除百日咳的关键。

This report summarized the data on the occurrence of pertussis, the pertussis vaccination and its serological surveillance during 1985-1995 in Xicheng District of Beijing from 1985 to 1995 The coverage rate of pertussis vaccine maintained a high level and the reported incidence of pertussis declined year by yearSince the absorbed DPT was adopted in 1990, the protective rate of pertussis antibody and it sgeometri cmean titre(GMT) increased obviously The vaccine efficacy showed that no pertussis cases occured during 1992-1995 It may be considered that increasing the protective rate and GMT of pertussis antibody is the key strategy for pertussis control and elimination, while maintaining a high-level coverage rate in population