四君子汤保护骨损伤后小鼠肠道细菌易位及促进骨修复的研究

Si Jun Zi soup prevent bacterium migration from after fracture of mice and promote fracture healing

目的观察四君子汤对骨损伤后小鼠免疫功能和细菌易位的影响,探讨中药在提高免疫力及预防感染方面的作用。方法通过制备小鼠股骨骨损伤模型,骨损伤后在腹腔注射抗生素的同时辅以四君子汤,观察四君子汤对小鼠吞噬细胞功能的影响和细菌易位的控制。结果骨损伤经四君子汤治疗后肝脏细菌易位明显减少(P<0.01);吞噬细胞功能显著增强(P<0.01);因有效控制了感染使骨修复过程加速。结论四君子汤能够保护骨损伤后小鼠肠道细菌易位和促进骨修复。

Objective To watch inhibition of Si Jun Zi soup to bacterium migration and improvtion immune systems, research function of traditional Chinese medicine to improve immune function and prevent infection. Method By doing fracture model of mice, treatment antibacterial and Si Jun Zi soup orally, watch immune fuction improve and inhibition bacterium migration. Result Bacterium migration of liver was decreased （ P 〈 0. 01 ）, immune cells function was increased（P 〈 0. 01 ） ,fracture healing was accelerated. Conclusion Si Jun Zi soup can inhibition bacterium migration and promote fracture healing.