咽舒饮泡腾片治疗慢性咽炎的药效学

Effect of Yanshuyin effervescence tablets on chronic pharyngitis

目的:研究咽舒饮泡腾片治疗慢性咽炎的药理作用及其机制。方法:采用二甲苯致小鼠耳廓肿胀,小鼠琼脂肉芽肿试验考察咽舒饮的抗炎作用;采用鸡红细胞致小鼠迟发型超敏反应试验,考察咽舒饮的抗过敏作用;采用小鼠气管酚红排泌试验,考察咽舒饮泡腾片的滋阴化痰作用;观察咽舒饮泡腾片对乙型溶血性链球菌、肺炎双球菌、金黄色葡萄球菌、大肠杆菌、绿脓杆菌5种较常见易感菌的体外抑菌和杀菌情况。结果:咽舒饮泡腾片可明显抑制二甲苯所致小鼠耳廓肿胀,抑制琼脂肉芽组织增生和鸡红细胞所致迟发型超敏反应,在实验剂量范围内呈剂量依赖性;在一定剂量时能抑制肉芽肿组织增生和使酚红排出量增多,其有广谱抑菌作用并对乙型溶血性链球菌显示出的抑菌作用和杀菌活性。结论:咽舒饮泡腾片具有较好的抗炎、抗过敏和一定的抑菌杀菌和滋阴化痰药理作用,对治疗咽炎有效。

OBJECTIVE To observe the effect of Yanshuyin effervescence tablets on chronic pharyngitis and investigate the pharmacological mechanism for clinical use and further research. METHODS Model of dimethylbenzene induced ear edema and cotton pill-implantation-induced hyperplasia in mice were used to study the anti-inflammatory effect of the tablets; Chicken red blood cells induced mice delayed-type hypersensitivity experiment was used to study its effect of anti-allergic; Mice trachea phenol red excretion experimental method was used to study the role of expelling phlegm; minimal inhibitory concentration and minimal bactericidal concentration of Yanshuyin to beta-hemolytic streptococcus, diplococcus pneumoniae, staphylococcus aureus, E. colt, pseudomonas aeruginosa, five commonly susceptible bacteria in vitro were also observed. RESULTS The tablets inhibit the dimethylbenzene induced mice ear edema and chicken red blood cells caused delayed-type hypersensitivity and the agar granuloma proliferation in the experimental; one of the low dose could inhibit the granuloma proliferation and make the phenol red excretion increased, it also showed a broad spectrum antibacterial activity and very good antibacterial and bactericid- al activity to Beta-hemolytic streptococcus. CONCLUSION Yanshuyin effervescence tablets have a good anti-inflammatory, anti-allergy, antibacteria effect and some anti-granuloma proliferation and expelling phlegm pharmacological effects. It is suit able for the treatment of pharyngitis.