实验性心肌梗塞犬血液流变性变化及葛根素对其的影响

EEEECT OF PUERARIN ON HEMORHEOLOGY IN DOGS WITH EXPERIMENTAL ACUTE MYOCARDIAL INFARCTION

本文观察了实验性心肌梗塞犬急性期１２项血液流变学指标的变化及中药葛根素对其的影响。结果显示：在心肌梗塞急性期，血小板聚集性、纤维蛋白原、血浆和全血粘度较梗塞前明显增高（Ｐ＜０．０５和Ｐ＜０．０１），而使用葛根素能阻止上述改变。提示该药能改善微循环，对缺血心有保护作用。

This study investigated the changes of twelve hemorheology indexes with or without puerarin administration in dogs with experimental acute myocardial infarction. The results showed that platelet aggregation,fibrinogen,plasma viscosity and whole blood viscosity increased during acute myocardial infarction when compared with control group (P < 0. 05 and P < 0. 0１),and the increased indexes during acute myocardial infarction would be inhibited when puerarin administration were given. This results indicate that puerarin can improve microcirculation and protect ischemic myocardium.