基因芯片技术在细菌学研究中的应用进展

Application Status of Gene Chip Technology in Bacteriology Research

基因芯片技术的诞生是基于人类基因组计划的成果,是融微电子学、生物学、物理学、化学、计算机科学为一体的新技术。能够广泛应用于基因表达分析、突变检测、核酸多态性分析、基因测序和药物筛选等几乎所有的生物学研究领域。综述了基因芯片技术的发展历史、原理、检测细菌的程序、在细菌学研究中的应用、存在的问题及其应用前景。

Gene chip technology is based on the achievements of human geneome project. It is a new technology combining microeletronics, biology, physics, chemistry, and computer science. It can be widely used in analysis of gene expression, mutation detection,analysis of nucleic acid polymorphism,gene sequencing,drug screening and so on in the field of biology research. The paper reviewed the development process of gene chip, principle, procedure of bacterium detection, application in biology research, existing problems and prospect.