中药治疗卡培他滨相关性手足综合征临床观察

Clinical Observation on Herbai Medicine for the Treatment of Hand-foot Syndrome Induced by Xeloda

目的:观察中药内服外洗治疗卡培他滨相关性手足综合征的疗效。方法:将卡培他滨相关性手足综合征大肠癌术后患者82人,随机分为中药组与对照组各41例。对照组进行化疗同时配合口服大剂量VitB_6,治疗组在化疗同时配合中药内服、外洗。比较2组患者手足综合征分级和卡培他滨调整剂量及停止用药例数。结果:治疗组中因严重手足综合征而永久停药发生率4.8%,明显低于对照组21.9%(P<0.05);治疗组中有70.0%患者能以原量完成全部6程化疗,而对照组为58.2%,2组比较,差异无显著性意义(P>0.05)。结论:中药外洗治疗卡培他滨相关性手足综合征,提高了患者对卡培他滨的耐受性和化疗通过率,改善了卡培他滨化疗患者的生活质量。

Objective:To observe the therapeutic effect of herbal medicine for the treatment of hand-foot syndrome induced by reloda.Methods:Eighty-two colorectal cancer patients with postoperative xelods-induced hand-foot syndrome were randomized into 2 groups:the control group received chemotherapy combined with oral use of large-dose VitB6,and the treatment group received chemotherapy combined with oral use and washing with herbal medicine.The grading of hand-foot syndrome,and the number of pstients with reduction of xelods dosage and suspension of xelods were observed.Results:The incidence of xelods suspension due to severe hand-foot syndrome was 4.8%in the treatment group,lower than 21.9%in the control group(P<0.05).Patients who finished all of the six chemotherapeutic courses accounted for 70.0%in the treatment group and 58.2%in the control group,the difference being insignificant between the two groups (P>0.05).Conclusion:Oral use and washing with herbal medicine can enhance the tolerance of patients to xeloda,increase the rate for finishing chemotherapy,and improve quality of life during the treatment of xeloda.