周围动脉硬化闭塞症血管内皮细胞损伤的观察

Observation of Vascular Endothelial Cell Injury in Patients with Peripheral Atherosclerosis Obliterans

目的：探讨血管内皮细胞损伤和肿瘤坏死因子在周围动脉硬化闭塞症发病中的临床意义。方法：对５０例老年闭塞性动脉硬化患者进行血浆内皮素、一氧化氮、肿瘤坏死因子及外周循环内皮细胞检查，检测方法分别为放射免疫测定、亚硝酸盐比色法和Ｔａｋａｈａｓｈｉ法。结果：５０例患者均呈高内皮素、高肿瘤坏死因子、低一氧化氮血症以及外周循环内皮细胞数目明显增加（Ｐ＜０．０１）现象，且同疾病严重程度密切相关。

bjective: To investigate the significance of vascular endothelial cell injury and tumor necrosis factor in peripheral atherosclerosis obliterans. Methods: Serum endothelin, serum nitric oxide, serum tumor necrosis factor and the number of peripheral circulating endothelial cells were determined in 50 patients with peripheral atherosclerosis obliterans by radioimmunoassay, colorimetry and takahashi method. Results: It was shown that all the patients had high levels of serum endothelin and of tumor necrosis factor, a lower level of serum nitric oxide and a significantly increased number of peripheral circulating endothelial cells, which closely related to the severity of the condition. Conclusion: It is suggested that injury of vascular endothelial cells and tumor necrosis factor participate in the pathogenesis and development of peripheral atherosclerosis obliterans. 