新疆维吾尔族慢性胃炎人群中HLA-DRB1*08等位基因与幽门螺杆菌感染的关系

Helicobacter pylori infection in Xinjiang Uygur nationality

目的:研究新疆维吾尔族慢性胃炎人群HLA DRB1*08等位基因与幽门螺杆菌感染的关系。方法:采用幽门螺杆菌分离培养技术检测慢性胃炎汉族36例,维吾尔族33例人群的幽门螺杆菌感染情况,并采用PCRSSP检测HLA-DRB1*08等位基因。结果:(1)新疆维吾尔族慢性胃炎人群H.pylori(Hp)阳性率为79%,高于汉族慢性胃炎人群(56%)(P<0.05)。(2)两组慢性胃炎人群Hp阳性组中HLA-DRB1*08等位基因频率在汉族为10.0%,在维吾尔族为15.4%,HLA-DRB1*08等位基因在汉族与维吾尔族慢性胃炎人群中检出频率无差异,维吾尔族与汉族慢性胃炎人群中HLA DRB1*08等位基因与Hp感染无关(P>0.05)。结论:(1)维吾尔族Hp感染率高于汉族慢性胃炎人群(P<0.05)。(2)维吾尔族与汉族慢性胃炎人群中HLA DRB1*08等位基因与H.pylori感染率无关。

Objective： To compare the prevalence of H. pylori infection in gastritis of Xinjiang Uygur, Han ethnic groups, and to analyze the association of HLA-DRB1 ＊ 08 allele of these two ethnic groups gastritis with H. pylori infection. Methods： Diagnosis by isolation of Hp from gastric biopsies for 36 Han and 33 Uygur chronic gastritis. Polymorase chain reaction single strand polymorphism （PCR-SSP） technique was applied to determine the polymorphism of the HLA-DRB1 ＊ 08 locus of these groups and the association of HLA-DRB1 ＊ 08 allele of these groups with Hp infection was analyzed by SPSS software. Results： The prevalence of Hp infection was 56% in Han nationality which was lower than the Uygur nationality （79%） （P 〈0. 05）. The distribution of HLA-DRB1 ＊ 08 locus was not significantly different between the 2 groups （P 〉0. 05）. Conclusion： The results indicated that the prevalence of Hp infection in Han and Uygur ethnic groups in Xinjiang Uygur was higher than that in Han ethnic group. HLA-DRB1 ＊ 08 allele have no relationship with Hp infection.